| 一种胶原蛋白寡肽体外透皮吸收性能研究 |
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| 引用本文： | 宋芹,陈封政,颜军,郭晓强,邬晓勇,苟小军. 一种胶原蛋白寡肽体外透皮吸收性能研究[J]. 成都大学学报(自然科学版), 2011, 30(1): 8-10,14 |
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| 作者姓名： | 宋芹 陈封政 颜军 郭晓强 邬晓勇 苟小军 |
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| 作者单位： | 成都大学中药化学实验室,四川成都,610106 |
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| 摘 要： | 为研究胶原蛋白寡肤的体外透皮吸收性能,采用体外透皮实验模型考察胶原蛋白寡肽(平均分子量920 Da,其中寡肽约占50%,三肤约占12%)对小鼠皮肤的透皮吸收性.结果表明,胶原寡肽24 h的累积渗透量为1160.3μg/cm2,体外渗透过程符合零级动力学方程,Q=41.574t+164.58,r=0.997,表现出良好的...
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| 关 键 词： | 胶原蛋白 寡肽 透皮吸收 |
Percutaneous Experimental Study on Collagen Oligopeptide |
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| SONG Qin,CHEN Fengzheng,YAN Jun,GUO Xiaoqiang,WU Xiaoyong,GOU Xiaojun. Percutaneous Experimental Study on Collagen Oligopeptide[J]. Journal of Chengdu University (Natural Science), 2011, 30(1): 8-10,14 |
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| Authors: | SONG Qin CHEN Fengzheng YAN Jun GUO Xiaoqiang WU Xiaoyong GOU Xiaojun |
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| Affiliation: | SONG Qin,CHEN Fengzheng,YAN Jun,GUO Xiaoqiang,WU Xiaoyong,GOU Xiaojun(Chemistry Laboratory of Traditional Chinese Medicine,Chengdu University,Chengdu 610106,China) |
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| Abstract: | To study the percutaneous absorption of the collagen oligopeptide to exsomatize rat skin,vitro penetration model was designed to investigate percutaneous absorption of collagen oligopeptide(the average molecular weight of peptid is 920 Da,50% of oligopeptide,12% of tripeptide) to rat skin.The results of the experiment show that the accumulative permeation quantity within twenty-four hours is 1 160.3 μg/cm2.The process of transdermal permeation of collagen oligopeptide corresponds to Zero-order kinetic equation of Q=41.574t+164.58,r=0.997 and collagen oligopeptide has good transdermal permeation property. |
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| Keywords: | collagen oligopeptide percutaneous absorption |
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