恒河猴和食蟹猴在结核病研究中的应用进展

摘要: 结核病是由结核分枝杆菌引起的慢性消耗性传染病，位居单一病原体引起死亡的严重传染病之首。结核病 历史悠久，对其记录可以追溯到远古社会。人类同结核病进行了数个世纪艰苦卓绝的斗争，然而，时至今日，结核 病仍是严重危害公众健康的全球性公共卫生问题。因此，研发有效的抗结核疫苗和药物迫在眉睫，而开展这些工 作需要合适的实验动物模型。由于非人灵长类动物在解剖结构、生理生化、免疫和代谢等生物学特性方面与人类 高度相似，应用非人灵长类实验动物对结核病的发病机制、机体免疫反应及相关疫苗和药物的深入研究至关重要， 甚至是不可替代的。本文着重就恒河猴和食蟹猴在人类结核病防治方面的研究进展进行综述。

Progress of Rhesus macaque and Cynomolgus macaque Models for Tuberculosis Study

Abstract: Tuberculosis ( TB) is a chronic wasting disease caused by Mycobacterium tuberculosis( Mtb) ，ranking the first death of a serious infectious disease by a single pathogen． TB has a long history，which can be traced back to the ancient society． For centuries，humans are extremely hard and bitter struggle with TB． To date，however，TB is still a serious public health problem world widely． Thus，there is urgent need to establish a suitable animal model for anti-TB vaccine and drug development． Nonhuman primates are evolutionarily close and similar to humans in terms of their characteristics of anatomy，physiology，immunology and biochemistry． Application of nonhuman primates as animal models for the study of the pathogenesis of TB，immune response and related vaccines and drugs is crucial，even irreplaceable． In this paper，we reviewed the recent advances in application of rhesus macaque and cynomolgus macaque models in research on TB prevention and treatment．