酒石酸衍生物的合成及其结构与光学活性关系的探讨

合成出系列的L-半螺旋型酒石酸衍生物1～6，测定比旋光度，发现酒石 酸二乙酯2([α]_D²⁵+3.00°，DMSO)形成2，3-O-亚异 丙基酒石酸二乙酯3后旋光急剧往左偏移([α]_D²⁵-45.03 °，DMSO])，3酰胺化后比旋光值往右偏移(4a ：+11.19°，4b：+2.14°)，还原产物的比 旋光值往左偏移(5a：-0.52°， 5b ：-4.92°，6：-2.95°)；并用分子的螺旋结构与基 团的极化性质研究旋光规律。

Studies on the Relationship between the Structures of Tartaric Acid Derivatives and Their Optical Activities

Several L-tartaric acid derivatives (1～6) were synthesized and their specific rotations were measured. It was found that diester 3 exhibited an unusually high negative value of specific rotation([α]_D²⁵-45.03 °，DMSO]), its amide derivative s 4 showed slightly positive specific rotation (4a:+11.19°,4b:+2.14°)，and the reduction products showed slightly negative values (5a:-0.52°, 5b:-4.92°，6：-2.95°). The optical activities o f 1～6 were elucidated by the polarization ability of functional gro ups and the helical structures.