Alteration of cholesterol synthesis in rat liver as induced by 4-methyl-5-hydroxy valeric acid |
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| Authors: | J. C. Díaz-Zagoya M. E. Hurtado J. González |
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| Affiliation: | (1) Departmento Bioquimica, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Apartado Postal 70-159, Mexico 20, D. F. |
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| Abstract: | Summary The rate of cholesterogenesis in rat liver, measured by the incorporation of labelled acetate or mevalonate into cholesterol, was significantly supressed by the use of 4-methyl-5-hydroxy valeric acid sodium salt. This effect cannot be explained by changes in HMG CoA reductase activity. |
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