In vitro effects of melanocytolytic agents and other compounds upon dominant human melanoma tyrosinase activity |
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| Authors: | Y. M. Chen W. Chavin |
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| Affiliation: | (1) Department of Biology, Wayne State University, 48202 Detroit, Michigan, USA |
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| Abstract: | Summary The activity of dominant human melanoma tyrosinase isozyme was greatly decreased by certain reducing agents. The number and geometry of phenolic groups as well as free-SH group appear important for enzymic inhibition.This investigation was supported by U.S. Public Health Service Research Grant No. CA-12731-02 and CA-15991-01 from National Cancer Institute. |
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