| 动物细胞培养过程中pH和溶氧的关联控制 |
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| 引用本文： | 顾小华,陈因良. 动物细胞培养过程中pH和溶氧的关联控制[J]. 华东理工大学学报(自然科学版), 1989, 0(4) |
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| 作者姓名： | 顾小华 陈因良 |
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| 作者单位： | 华东化工学院生化工程研究所(顾小华)，华东化工学院生化工程研究所(陈因良) |
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| 摘 要： | 本文通过对动物细胞培养过程中pH值和溶氧(DO)水平控制要求的分析,设计了用空气、氧气、氮气和二氮化碳四组气体关联控制pH值和DO水平的控制系统。该系统根据对瞬时pH值和DO值参数的检测,通过微处理机进行一系列的逻辑判断和具有PI调节规律的DDC增量词节计算,再经四气体关联互补计算和多重时序控制环节,综合调节四组气体电磁阀的相互开闭时间,实现对培养过程中pH值和DO水平的控制,满足动物细胞生长的需要。
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| 关 键 词： | 细胞培养 控制系统 补偿电路 时序控制 pH和DO相关控制 互补计算 |
Interactive Control of pH and DO in the Animal Cell Culture |
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| Gu Xiaohua Chen Yinliang. Interactive Control of pH and DO in the Animal Cell Culture[J]. Journal of East China University of Science and Technology, 1989, 0(4) |
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| Authors: | Gu Xiaohua Chen Yinliang |
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| Affiliation: | Research Institute of Biochemical Engineering |
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| Abstract: | A new design of interactive control scheme is presented for the regulation of pH and DO in the mass culture of animal cells. It is simply composed of four-gas (air, oxygen, carbon dioxide and nitrogen) coupling compensating calculation (CCC) and multiple-sequence-control (MSC). By a series of logic judgements of signals from sensors and direct digital calculations (DDC), a simple proportional plus integral (PI) controller can manipulate the operations of electrocegnetic valves to meet the requirements of pH and DO levels in the growth and metabolism of animal cells. |
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| Keywords: | cell culture control systems compensation networks sequential control interactive control of pH and DO compensating calculation |
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