Stable isotopes of lithium: dissimilar biochemical and behavioral effects |
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Authors: | K. Lieberman G. J. Alexander J. A. Sechzer |
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Affiliation: | (1) Laboratory of Psychopharmacology, Catholic Medical Center of Brooklyn and Queens, 88-25 153rd Street, 11432 Jamaica, New York, USA;(2) Dept of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts, USA;(3) College of Physicians and Surgeons, New York State Psychiatric Institute and Columbia University, New York, New York, USA;(4) Bourne Behavioral Research Laboratory, Dept of Psychiatry, New York Hospital-Cornell Medical Center, White Plains, New York, USA |
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Abstract: | Summary Lithium, which is used routinely in the treatment of mania, is composed of two stable isotopes, lithium-7 (92.58%) and lithium-6 (7.42%). Usually there is minimal physiological or biochemical differentiation between isotopes of an element, but lithium is an exception. Data derived from a variety of biochemical and behavioral experiments are reviewed to support this idea. Additionally, the clinical implications of this work are presented. |
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Keywords: | Lithium isotopes lithium-6 lithium-7 mania |
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