Quantification of melanin in hepatic and cardiac lipofuscin |
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| Authors: | L M Ambani J W Jhung L M Edelstein M H Van Woert |
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| Institution: | (1) Departments of Internal Medicine and Pharmacology, Yale University School of Medicine, 06510 New Haven, Connectitut, (USA);(2) Department of Pathology and Medicine, St. Vincent Hospital, 01610 Worcester, Massachusetts, (USA);(3) University of Massachusetts Medical School, 01610 Worcester, Massachusetts, (USA);(4) Department of Neurology, Mount Sinai School of Medicine, Fifth Ave. and 100th Street, 10029 New York, N. Y., USA |
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| Abstract: | Summary Melanin pigment in liver and heart tissue, obtained at autopsy from patients, was isolated and quantified. The quantity of melanin extracted was directly proportional to lipofuscin granule counts. Infrared and electron spin resonance spectrographs of the isolated pigments from liver and heart showed absorption characteristics identical to those of known melanins. The pigment was absent in fetal and neonatal life, increased in brown atrophy of the heart and liver, and diminished in livers with fatty metamorphosis.Supported by USPHS, grant NS 07542, the St. Vincent Hospital Research Foundation and the Dermatopathology Foundation. |
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