低温条件下山莨菪碱对缺血再灌注损伤期肾内前列腺素的影响

目的：研究低温条件下山莨菪三兔肾缺血再灌注损伤期肾内前列腺素的影响及肾功能的保护作用。方法：在兔肾缺血再灌注损伤模型上，分别 检测假手术（无缺血组）、对照组（缺血再灌注损伤组）、山莨菪硷治疗组、低温治疗组低温条件下山莨菪碱组缺前和恢复血液灌注２４h的肾组织血栓素Ｂ２（ＴＸＢ２），６－酮－前列腺素Ｆ１α（６－Keto-PGF1α）的含量以及检测各组恢复血液灌注２４h各组血肌酐）ＳＣr)、尿素氯（ＢuN）含量。结果：山莨菪 硷组和低温组、低温条件下山莨菪碱治疗组ＴＸＢ、６－Keto-PGF1α、血肌酐（ＳCr),、尿素氮（ＢuN）及６－Keto-PGF1α／ＴＸＢ２（Ｋ／Ｔ）与对照组相比较有显著性差异（Ｐ＜０．０５），低温条件下山莨菪碱治疗组优于山菪硷组和低温（Ｐ＜０．０５）。结论菪硷 与低低温改善肾内前列环素（ＰＧＩ２（）－血栓素Ａ２（ＴＸＡ２）平衡紊乱，对兔肾缺血再灌注损伤均有一定的保护作用。低温条件下山莨菪碱更能够有效纠正肾内ＰＧＩ２－ＴＸＡ２平衡紊乱，改善肾内微循环，明显优于山劳苦 硷或低温单独应用。

The effect of anisodamine on rabbit renal ischemia-reperfusion injury in with condition of cooling prostaglandin of kidney tissue

Aim: To investigate the effect of anisodamine on prostaglandin of kidney tissue on rabbit renal ischemia-reperfusion injury with of cooling conditions. Methods: Based on the rabbit renal ischemia-reperfusion model, 50 rabbits were randomly divided into five groups: group 1 (sham operation), group 2 (control), group 3 (anisodamine treatment), group 4 (cooling) group 5 (anisodamine with cooling condition). Kidney tissue TXB2, 6-Keto-PGF1α concentration of preischemia and postreperfusion 24 hours were detected in respectively. Level of SCr, BuN were detected in respective groups after recovering blood flow 24 hours. Results: There were significant increase in SCr, BuN and tissue 6Keto-PGF1α and K/T ratio levels, and a significant decrease in the tissue TXB2 in group 5 when compared with group 3 or group 4. Conclusion: Balance disorder of PGI2 - TXA2 could be improved and ischemia- reperfusion injury be inhibitated by group 3 or group 4, but group 5 was significantly better compared with group 3 or group 4.