Identification of large ancient duplications associated with human gene deserts |
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Authors: | Itoh Takehiko Toyoda Atsushi Taylor Todd D Sakaki Yoshiyuki Hattori Masahira |
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Affiliation: | Research Center for Advanced Science and Technology, Mitsubishi Research Institute, Inc., Tokyo 100-8141, Japan. takehiko@mri.co.jp |
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Abstract: | We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor. |
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