Gastrin: Obligatory intermediate in the postprandial mobilization of gastric histamine in the rat |
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| Authors: | R Håkanson J Hedenbro G Liedberg H A El Munshid J F Rehfeld |
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| Institution: | (1) Departments of Pharmacology and Surgery, University of Lund, Lund, Sweden;(2) Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark |
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| Abstract: | Summary In unoperated fasted rats, feeding raised the serum gastrin concentration, reduced the gastric mucosal histamine content and activated the gastric histidine decarboxylase. The reduction of gastric histamine and activation of histidine decarboxylase was induced also by the injection of pentagastrin. In antrectomized rats, feeding failed to produce these effects. Injection of pentagastrin, however, still lowered gastric histamine and activated gastric histidine decarboxylase. Thus, antral gastrin seems to be an obligatory mediator of the postprandial activation of histidine decarboxylase and mobilization of histamine.Acknowledgments. Grant support from the Swedish and Danish Medical Research Councils (14P-4822, 04X-1007, 17X-4144 and 512-2540). |
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