呋喃二烯纳米结构脂质载体的制备及包封率的研究

选择固体脂质单硬脂酸甘油酯和液态油辛酸／癸酸三甘油酯，以制备一种新型固体脂质纳米粒——呋喃二烯纳米结构脂质载体（FN—NLC）传递系统，并考察其理化性质．采用热融一超声分散法制备FN—NLC．以包封率、平均粒径和Zeta电位为指标，考察了脂质的种类、固体和液态脂质的比例、乳化剂的种类和用量等影响因素．经单因素考察和正交试验设计优选，确定单硬脂酸甘油酯与辛酸／癸酸三甘油酯为脂质材料，所制备的FN—NLC的平均粒径为125．1nm，Zeta电位30．19mV，多分散系数0．201，载药量4．2％，包封率93．5％．于4℃放置6个月，平均粒径、Zeta电位、包封率无明显变化．本研究为NF—NLC的研究和开发奠定了基础．

Study on Preparation and Entrapment Efficiency of Nanostructured Lipid Carriers(NLC) of Furanodiene

The preparation of Novel Solid Lipid Nanoparticle for furanodiene （FN-NLC） with monostearin and caprylie/eapric triglyeerides are used to prepare isstudied, and physicochemieal properties of the carriers is investigated. Novel FN-NLC is prepared by the meit-uhrasoie technique and the carriers materials are chosen based on single factor experiment and orthogonal experiments. According to the entrapment efficiency, mean droplet size and zeta potential the effects of lipid types, the proportion between solid lipid and liquid lipid, the types and the amount of the emulgators are optimized. Novel FN-NLC made by monostearin and caprylie/caprie triglyeerides are chosen. The average size is 125.1 nm; the Zeta potential is -30.19 mV; the dispersion efficiency is 0. 201 ; the drug loading capacity is 4.2% ; the entrapment efficiency is 93.5%. Ffter storage at 4℃ for 6 months there is no significant change in the average droplet size, Zeta potential and entrapment efficiency. The preparation of FN - NLC could contribute to further research and development.