A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice |
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| Authors: | M C Nussenzweig E V Schmidt A C Shaw E Sinn J Campos-Torres B Mathey-Prevot P K Pattengale P Leder |
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| Institution: | Department of Genetics, Howard Hughes Medical Institute, Boston, Massachusetts. |
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| Abstract: | Transgenic mice carrying an immunoglobulin enhancer-driven c-myc oncogene develop rapid-onset pre-B cell lymphomas. The incidence of these malignancies is greatly reduced when an additional transgene encoding the membrane-bound form (but not the secreted form) of human Ig mu is bred into the susceptible strain. This suppressive effect correlates with a subtle alteration in B-cell development induced by the immunoglobulin transgene. |
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