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Induction of hemopoietic chimerism in the caprine fetus by intraperitoneal injection of fetal liver cells
Authors:R D Pearce  D Kiehm  D T Armstrong  P B Little  J W Callahan  L R Klunder  J T R Clarke
Institution:(1) Department of Pediatrics and University of Toronto, The Hospital for Sick Children, M5G 1X8 Toronto, Ontario, Canada;(2) MRC Group in Reproductive Biology, University Hospital, N6A 5A5 London, Ontario, Canada;(3) Department of Pathology, Ontario Veterinary College, University of Guelph, N1G 2W1 Guelph, Ontario, Canada;(4) Cytogenetics Laboratory, George D. Widener Hospital for Large Animals, New Bolton Center, University of Pennsylvania, 19348 Kennett Square, Pennsylvania, USA
Abstract:Summary Intraperitoneal injection of allogeneic liver cells from 43-day-old male fetuses into normal 60-day female goat fetuses resulted in persistent hemopoietic chimerism in surviving recipients without clinical evidence of graft-versus-host disease. Transplantation of normal fetal liver cells into preimmunocompetent goat fetuses affected with beta-D-mannosidosis may provide an alternative strategy for evaluating hemopoietic stem cell transplantation in the treatment of human lysosomal storage diseases.
Keywords:Transplantation  goat  fetal liver  beta-D-mannosidosis" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">-D-mannosidosis  hemopoietic chimerism
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