| 乙酰胺基丙二酸二乙酯合成方法的改进 |
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| 引用本文： | 王心良,李崇熙. 乙酰胺基丙二酸二乙酯合成方法的改进[J]. 西华师范大学学报(哲学社会科学版), 1997, 0(1) |
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| 作者姓名： | 王心良 李崇熙 |
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| 作者单位： | 四川师范学院化学系(王心良)，北京大学化学系(李崇熙) |
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| 摘 要： | 合成乙酰胺基丙二酸二乙酯系一经典反应，实际收率常常远低于文献值．在经典合成法的基础上，作者探索出一新的合成操作方案，由此得到了稳定的、高于文献收率的目标产物，同时消除了不安全因素．
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| 关 键 词： | 乙酰胺基丙二酸二乙酯，非天然氨基酸，合成方法，改进 |
THE SYNTHESIS OF THE DIETHYL ACETO AMIDOMALONATE WITH AN IMPROVED METHOD |
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| Abstract: | The synthesis of diethyl acetamidomalonate from diethyl malonate is a classical reaction,whose total yield is usually much lower than that recorded in the literature.On the basis of the classical method,a new method is introduced,which helps to obtain a stable and increased yield(up to 85%),and to remove the unsafe factors as well,the method proves to be superior to the classical one. |
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| Keywords: | diethyl acetamidomalonate non protein amino acid synthesis method improvement. |
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