The role of conjugative transposons in spreading antibiotic resistance between bacteria that inhabit the gastrointestinal tract |
| |
Authors: | Scott K P |
| |
Institution: | (1) Gut Microbiology and Immunology Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB (United Kingdom), Fax: +44(0)1224716687, e-mail K.Scott@rri.sari.ac.uk, GB |
| |
Abstract: | There is huge potential for genetic exchange to occur within the dense, diverse anaerobic microbial population inhabiting
the gastrointestinal tract (GIT) of humans and animals. However, the incidence of conjugative transposons (CTns) and the antibiotic
resistance genes they carry has not been well studied among this population. Since any incoming bacteria, including pathogens,
can access this reservoir of genes, this oversight would appear to be an important one. Recent evidence has shown that anaerobic
bacteria native to the rumen or hindgut harbour both novel antibiotic resistance genes and novel conjugative transposons.
These CTns, and previously characterized CTns, can be transferred to a wide range of commensal bacteria under laboratory and
in vivo conditions. The main evidence that gene transfer occurs widely in vivo between GIT bacteria, and between GIT bacteria
and pathogenic bacteria, is that identical resistance genes are present in diverse bacterial species from different hosts. |
| |
Keywords: | , Anaerobic, commensal bacteria, conjugative transposons, TnB1230, tetracycline resistance, gene transfer, gastrointestinal,,,,,tract, rumen, |
本文献已被 PubMed SpringerLink 等数据库收录! |
|