Graft-versus-host reaction and lymphoid organs in normally fed and protein-deprived rats |
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| Authors: | A Aschkenasy |
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| Institution: | (1) Centre Marcel Delépine, Laboratoire d'Hématologie Nutritionnelle, Centre National de la Recherche Scientifique, F-45045 Orléans Cedex, France |
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| Abstract: | Summary Lymph node graft-versus-host reaction (GVHR) induced by parental splenic lymphocytes inoculated into hind foot pads of F-1 hybrid rats is correlated with the state of the thymus and the spleen of the recipients. This may explain the depression of the reaction after protracted protein deprivation. Furthermore, GVHR provokes mainly in normal rats a reduction of thymus and spleen possibly due to a T-cell transfer to the grafted area.I thank Mrs.M. Cl. Gonzalez and Mr.D. Soulas (C.N.R.S.) for their skilled technical assistance. |
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