| 卵巢癌中的表观遗传修饰 |
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| 引用本文： | 代葳. 卵巢癌中的表观遗传修饰[J]. 辽宁大学学报(自然科学版), 2006, 33(4): 353-357 |
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| 作者姓名： | 代葳 |
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| 作者单位： | 中国医科大学,生物化学系,辽宁,沈阳,110001 |
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| 摘 要： | 介绍了在卵巢癌的发展和治疗中表观遗传学的重要性，特别强调了在卵巢癌中内源性和获得性耐药性遗传途径中异常的DNA甲基化和组蛋白去乙酰化的重要性．通过表观遗传治疗反转肿瘤抑制基因沉寂和其他参与药物级联反应的基因沉寂为出现耐药性的卵巢癌患者带来了新的希望．
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| 关 键 词： | 卵巢癌 表观遗传学 基因芯片 DNA甲基化 组蛋白乙酰化 |
| 文章编号： | 1000-5846（2006）04-0353-05 |
| 收稿时间： | 2006-05-17 |
| 修稿时间： | 2006-05-17 |
Epigenetic Modification of Ovary Cancer |
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| DAI Wei. Epigenetic Modification of Ovary Cancer[J]. Journal of Liaoning University(Natural Sciences Edition), 2006, 33(4): 353-357 |
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| Authors: | DAI Wei |
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| Affiliation: | Department of Biochemistry, China Medical University, Shenyang 110001, China |
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| Abstract: | This paper highlights a prominent role for epigenetics, particularly aberrant DNA methylation and histone acetylation, in both intrinsic and acquired drug- resistant genetic pathways in ovarian cancer. In this review, we summarize recent advances in the study of epigenetics. Moreover, when combined with conventional chemotherapeutic agents, epigenetic -based therapies may provide a way to resensitize ovarian tumors to the proven cytotoxic activities of conventional chemotherapeutics. |
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| Keywords: | ovarian cancer epigenetics microarray DNA methylation histone acetylation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
