| 木芙蓉叶有效组分对大鼠肾缺血再灌注损伤的保护作用 |
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| 引用本文： | 符诗聪,罗仕华,周玲珠,张凤华. 木芙蓉叶有效组分对大鼠肾缺血再灌注损伤的保护作用[J]. 广西科学, 2004, 11(2): 131-133 |
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| 作者姓名： | 符诗聪 罗仕华 周玲珠 张凤华 |
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| 作者单位： | 上海第二医科大学附属瑞金医院伤科,上海伤骨科研究所,上海市瑞金二路197号,200025;上海第二医科大学附属瑞金医院生化室,上海市瑞金二路197号,200025 |
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| 基金项目： | 上海市教委资助重点课题 (课题编号 :0 1B11) |
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| 摘 要： | 为了探讨木芙蓉叶有效组分 (MFR)对大鼠肾缺血再灌注损伤中的作用 ,采用大鼠肾缺血再灌注模型 ,木芙蓉叶有效组分灌胃给药 ,观察血清尿素氮 (BUN)、肌酐 (Scr)及肾组织病理变化 ,并检测白细胞介素 - 1(IL- 1 )的含量。结果再灌注 2 4 h后 ,治疗组血 BUN及 Scr明显降低 (P <0 .0 5 ) ;治疗组血液 IL- 1含量与非治疗组相比有显著性差异 (P <0 .0 5 ) ;而且治疗组肾组织病理损伤较非治疗组明显减轻。木芙蓉叶有效组分对肾缺血再灌注损伤有保护作用 ,其原因可能与抑制 IL- 1等的生成有关
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| 关 键 词： | 有效组分 木芙蓉叶 肾缺血再灌注 血清尿素氮 肌酐 白细胞介素-1 |
| 收稿时间： | 2003-11-19 |
| 修稿时间： | 2003-11-19 |
Effect of Leaves of Hibiscus mutabilis L.on Renal Ischemia Reperfusion Injury of Rat Model |
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| Fu Shicong,Luo Shihu,Zhou Lingzhu and Zhang Fenghua. Effect of Leaves of Hibiscus mutabilis L.on Renal Ischemia Reperfusion Injury of Rat Model[J]. Guangxi Sciences, 2004, 11(2): 131-133 |
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| Authors: | Fu Shicong Luo Shihu Zhou Lingzhu Zhang Fenghua |
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| Affiliation: | Fu Shicong1 Luo Shihua1 Zhou Lingzhu2 Zhang Fenghua1 |
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| Abstract: | To explore the role of effective fraction of Hibiscus mutabilis L (MFR) on renal ischemia reperfusion injury in rat Using a model of renal ischemia reperfusion injury,determined the change of blood urea nitrogen (BUN),serum creatinine(Scr),the pathological change of kidney tissue and the level of interleukin 1(IL 1) after the Hibiscus mutabilis L was administrated Results At 24 h after reperfusion,the BUN and Scr level decreased significantly in MFR group (P<0 05) The level of IL 1 was marked difference between MFR group and blank group (P<0 05) The renal pathological injury of MFR group was mitigated significantly The results suggest that Hibiscus mutabilis L protects kidney from ischemia reperfusion injury,and that this action may underline its inhibitory action on the interleukin 1 releasing |
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| Keywords: | effective fraction leaves of Hibiscus mutabilis L renal ischemia reperfusion blood urea nitrogen serum creatinine interleukin-1 |
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