Antimutagenic unusual amino acids from plants |
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Authors: | H Minakata H Komura S Y Tamura Y Ohfune K Nakanishi T Kada |
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Institution: | (1) Suntory Institute for Bioorganic Research, SUNBOR, Wakayama-dai, Mishima-gun, 618 Osaka, Japan;(2) National Institute of Genetics, 411 Mishima, Shizuoka, Japan |
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Abstract: | Summary Five unusual amino acids were identified as antimutagens against spontaneous mutation ofSalmonella typhimurium TA100: L-azetidine-2-carboxylic acid (1) from Liliaceae plants, -(methylenecyclopropyl)glycine (2) fromLitchi chinensis seeds, and 2-amino-4-methylhex-5-ynoic acid (3), hypoglycin A (4), and (2S, 4R)-2-amino-4-hydroxyhept-6-ynoic acid (5) fromEuphoria longana seeds. The absolute stereochemistry of5 was determined by its chiral synthesis from L-allylglycine, proving that5 is the C-4 epimer of the amino acid previously isolated from dried longan seeds.This work was partly supported by a Grant-in-Aid form the Ministry of Education, Science, and Culture, Japan, No. 57740283 (to HK). |
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Keywords: | Antimutagens natural product unusual amino acids isolation and structural determination Liliaceae Sapindaceae Salmonella typhimurium TA100 |
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