| 雷福尔马茨基反应在制药上的应用进展 |
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| 引用本文： | 吴晓,朱友良.雷福尔马茨基反应在制药上的应用进展[J].江西科学,2006,24(6):534-537. |
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| 作者姓名： | 吴晓 朱友良 |
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| 作者单位： | 1. 江西省科学院能源研究所,江西,南昌,330029
2. 衢州学院,浙江,衢州,324000 |
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| 摘 要： | Reform atsky试剂是一种应用较多的精细有机合成试剂,由于用该试剂比较容易进行Reform atsky反应,因而新的应用经常被开发。用该试剂进行Reform atsky反应可合成强效镇痛药“依那朵林”的中间体4-苯并呋喃乙酸,以及具有强心作用的“强心甾”等上佳的医药,也可合成很有应用价值的药物萜类化合物“甲瓦龙酸内酯”等。
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| 关 键 词： | 雷福尔马茨基试剂 依那朵林 4-苯并呋喃乙酸 强心甾 甲瓦龙酸内酯 |
| 文章编号： | 1001-3679(2006)06-0534-04 |
| 收稿时间： | 2006-10-12 |
| 修稿时间： | 2006-11-12 |
Actions and Some New Applications in Pharmacy of Reformatsky Reagent with Reaction |
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| WU Xiao,ZHU You-liang.Actions and Some New Applications in Pharmacy of Reformatsky Reagent with Reaction[J].Jiangxi Science,2006,24(6):534-537. |
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| Authors: | WU Xiao ZHU You-liang |
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| Institution: | 1. Institute of Energy,Jiangxi Academy of Sciences ,Jiangxi Nanehang 330029 PRC; 2. Quzhou College, Zhejiang Quzhou 324000 PRC |
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| Abstract: | Reformatsky is a kind of reagents more applied in fine organic synthesis.Because of the reagent used more easily in Reformatsky reaction,so new applications are often developed.4-Benzofuranacetic acid,a pharmaceutical intermediate compound of "enadoline" with powerful analgesic effect,can be synthesized by the reagent in Reformatsky reaction.And "cardenolide"nedicine with strengthen the function of the heart,"mevalomic lactone" terpene compound with medicinal value can also be synthesized. |
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| Keywords: | Reformatsky reagent Enadoline 4-benzofuranacetic acid Ecardenolide Mevalomic lacton |
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