Nitrate and nitrite transport in bacteria |
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Authors: | J W B Moir N J Wood |
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Institution: | (1) Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN (United Kingdom), Fax +44 114 272 8697, e-mail: j.moir@sheffield.ac.uk , UK |
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Abstract: | The topological arrangements of nitrate and nitrite reductases in bacteria necessitate the synthesis of transporter proteins
that carry the nitrogen oxyanions across the cytoplasmic membrane. For assimilation of nitrate (and nitrite) there are two
types of uptake system known: ABC transporters that are driven by ATP hydrolysis, and secondary transporters reliant on a
proton motive force. Proteins homologous to the latter type of transporter are also involved in nitrate and nitrite transport
in dissimilatory processes such as denitrification. These proteins belong to the NarK family, which is a branch of the Major
Facilitator Superfamily. The mechanism and substrate specificity of transport via these proteins is unknown, but is discussed
in the light of sequence analysis of members of the NarK family. A hypothesis for nitrate and nitrite transport is proposed
based on the finding that there are two distinct types of NarK. |
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Keywords: | , Nitrate, nitrite, transporter, dissimilatory, assimilatory, NarK, |
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