| 天然丝素制备三维多孔支架 |
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| 引用本文： | 林静,马西兰,曹传宝. 天然丝素制备三维多孔支架[J]. 北京理工大学学报, 2011, 31(9): 1109-1113 |
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| 作者姓名： | 林静 马西兰 曹传宝 |
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| 作者单位： | 北京理工大学材料学院,北京,100081 |
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| 基金项目： | 国家“八六三”计划项目(2006AA03Z450,2006AA02A134) |
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| 摘 要： | 研究盐沥滤法制备三维多孔丝素支架,在丝素多孔支架上培养人成骨肉瘤细胞、成纤维细胞及肝细胞.研究材料的细胞相容性,发现多种动物细胞在盐沥滤法所制备的丝素多孔支架材料上能够很好地黏附和增殖.通过调整丝素水溶液的浓度、溶解丝素溶剂体系、NaCl添加量和NaCl粒径,制备出结构和性质可以调控的三维支架.该结果为丝素多孔支架材料的制备提供了新的研究思路和方法.
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| 关 键 词： | 丝素蛋白 多孔支架 盐沥滤法 细胞相容性 生物材料 |
| 收稿时间： | 2010-06-05 |
Preparation of 3D Porous Silk Fibroin Scaffold |
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| LIN Jing,MA Xi-lan and CAO Chuan-bao. Preparation of 3D Porous Silk Fibroin Scaffold[J]. Journal of Beijing Institute of Technology(Natural Science Edition), 2011, 31(9): 1109-1113 |
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| Authors: | LIN Jing MA Xi-lan CAO Chuan-bao |
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| Affiliation: | LIN Jing,MA Xi-lan,CAO Chuan-bao(School of Material Science and Engineering,Beijing Institute of Technology,Beijing 100081,China) |
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| Abstract: | A new salt leaching method was developed to make 3D porous silk fibroin scaffolds.The human osteosarcoma cells(MG-63),fibroblasts(NIH-3T3) and liver cells(HepG2) were cultured on the porous silk fibroin scaffolds and the cells compatibility on the scaffold was investigated.It is found that the cell compatibility is good and the structure and property of 3D scaffold could be controlled by adjusting the concentration of silk fibroin aqueous solution,dissolved fibroin solvent system,the amount of salt added an... |
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| Keywords: | silk fibroin porous scaffold salt leaching cell compatibility biomaterial |
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