| 1,3-二氮杂环并[1,2-c] -1,2,3-三唑的简便合成 |
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| 引用本文： | 郝晓盼,姜秀阳,林军,严胜骄. 1,3-二氮杂环并[1,2-c] -1,2,3-三唑的简便合成[J]. 云南大学学报(自然科学版), 2015, 37(5): 766-769. DOI: 10.7540/j.ynu.20150231 |
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| 作者姓名： | 郝晓盼 姜秀阳 林军 严胜骄 |
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| 作者单位： | 1.云南大学 化学科学与工程学院, 教育部自然资源药物化学重点实验室, 云南 昆明 650091 |
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| 摘 要： | 以DMF为介质,90 ℃条件下,2,4,6-三叠氮基均三嗪2与杂环烯酮缩胺3反应,简洁、高效合成1,3-二氮杂环并[1,2-c]-1,2,3-三唑4.2,4,6-三叠氮基均三嗪2作为叠氮的高效载体,使反应在较温和条件下进行.该反应具有时间短、操作简便、产率高(89%~93%)等特点.
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| 关 键 词： | 三聚氯氰 杂环烯酮缩胺 1 2 3-三唑 |
| 收稿时间： | 2015-04-29 |
A convenient synthesis of 1,3-diazaheterocycle-fused[1,2-c]-1,2,3-triazoles |
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| HAO Xiao-pan,JIANG Xiu-yang,LIN Jun,YAN Sheng-Jiao. A convenient synthesis of 1,3-diazaheterocycle-fused[1,2-c]-1,2,3-triazoles[J]. Journal of Yunnan University(Natural Sciences), 2015, 37(5): 766-769. DOI: 10.7540/j.ynu.20150231 |
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| Authors: | HAO Xiao-pan JIANG Xiu-yang LIN Jun YAN Sheng-Jiao |
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| Affiliation: | 1.Key Laboratory of Medicinal Chemistry for Natural Resource(Ministry of Education), School of Chemical Science and Technology, Yunnan University, Kunming, 650091, China |
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| Abstract: | An efficient and simple synthetic protocol for 1,3-diazaheterocycle-fused[1,2-c] -1,2,3-triazoles4 has been developed.The strategy involves the reaction of 2,4,6-triazido-1,3,5-triazine 2 and heterocyclic ketene aminals (HKAs)3 in DMF medium at 90 ℃.Compound 2 has been used as the substrate efficiently providing the azide groups.This method has the advantages such as mild reaction conditions,operational simplicity and excellent yields (89%93%). |
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| Keywords: | cyanuric chloride heterocyclic ketene aminals 1 2 3-triazoles |
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