High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. |
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| Authors: | B L Hempstead D Martin-Zanca D R Kaplan L F Parada M V Chao |
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| Institution: | Department of Medicine, Cornell University Medical College, New York, New York 10021. |
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| Abstract: | Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor. |
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