| 无标记生物检测中微悬臂层合梁的纳米热机变形 |
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| 引用本文： | 邢晶晶,张能辉,郑晋.无标记生物检测中微悬臂层合梁的纳米热机变形[J].上海大学学报(自然科学版),2006,13(3):266-268. |
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| 作者姓名： | 邢晶晶 张能辉 郑晋 |
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| 作者单位： | 1．上海大学 上海市应用数学和力学研究所，上海 200072； ;2．上海大学 理学院，上海 200444；;3．上海大学 机电工程与自动化学院，上海 200072 |
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| 基金项目： | 上海市重点学科建设项目;上海市高等学校优秀青年教师后备人选计划 |
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| 摘 要： | 以无标记生物检测引起的探针挠度为未知量，放弃单向受力假设，建立了在杂交表面应力和热载荷作用下生物探针纳米力学行为的连续介质力学层合梁模型.分别采用线性和均匀温度场模拟了生物探针在生物化学反应中的瞬态和稳态温度分布，从而解释了Fritz有关DNA分子杂交实验中的双金属效应.
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| 关 键 词： | 纳米热机变形 微悬臂层合梁 无标记生物检测 杂交表面应力 |
| 文章编号： | 1007-2861（2006）03-0266-03 |
| 收稿时间： | 2005-08-31 |
| 修稿时间： | 2005-08-31 |
Nano-Thermomechanical Deformation of a Microcantilever Laminated Beam in Label-Free Biodetection |
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| XING Jing-jing,ZHANG Neng-hui,ZHENG Jin.Nano-Thermomechanical Deformation of a Microcantilever Laminated Beam in Label-Free Biodetection[J].Journal of Shanghai University(Natural Science),2006,13(3):266-268. |
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| Authors: | XING Jing-jing ZHANG Neng-hui ZHENG Jin |
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| Institution: | 1. Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China;;2. School of Sciences, Shanghai University, Shanghai 200444, China;;3. School of Mechatronial Engineering and Automation, Shanghai University, Shanghai 200072, China |
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| Abstract: | Abandoning the uniaxial stress assumption,a continuum laminated beam model in terms of deflection induced by label-free biodetections is set up to study nanomechanical behaviors of a biodetector subjected to hybridization surface stresses and thermal loads.Linear and uniform temperature fields are used separately to simulate transient and steady temperature distributions in biochemical reactions in order to explain the bimetallic effects in Fritz's experiments on DNA hybridizations. |
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| Keywords: | label-free biodetection hybridization surface stress nano-thermomechanical deformation microcantilever laminated beam |
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