Hormonal manipulation of carrageenin-induced pyresis in rats |
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| Authors: | R. W. Trottier Jr E. Moore J. McMillan N. Evans |
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| Affiliation: | (1) School of Pharmacy, Florida A and M University, 32307 Tallahassee, Florida, USA |
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| Abstract: | Summary The intensity of the hyperthermic response in rats promoted by subplantar injection of 1 mg of carrageenin is directly related to the irritant properties of the type of carrageenin. The overall pyretic response is more dramatic in female rats than in male rats. Subtle changes in the time-course hyperthermic profiles are seen after hormonal modifications.This work was supported by NIH, MBS research grant No. RR08111. |
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