| 新型光敏剂的合成研究 |
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| 引用本文： | 王红军,刘百超,孙俊永. 新型光敏剂的合成研究[J]. 信阳师范学院学报(自然科学版), 2007, 20(4): 475-478 |
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| 作者姓名： | 王红军 刘百超 孙俊永 |
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| 作者单位： | 信阳师范学院,河南,信阳,464000 |
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| 摘 要： | 在醋酸和醋酐溶剂中,用硝酸盐作硝化剂,与四苯基金属卟啉进行区域选择性硝化反应,制备了一系列新型用于光动力治疗光敏剂研究的2-硝基-四(3-甲氧基苯基)卟啉,产率达90%以上.用红外光谱、紫外-可见光谱、核磁共振谱和质谱对这些化合物进行了分析和鉴证,各项指标均符合要求.
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| 关 键 词： | 光敏剂 2-硝基-5,10,15,20-四(3-羟基苯基)金属卟啉 合成 光动力治疗 |
| 文章编号： | 1003-0972（2007）04-0475-04 |
| 收稿时间： | 2006-11-07 |
| 修稿时间： | 2007-01-29 |
Research for Synthesis of Novel Photosensitizer |
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| WANG Hong-jun,LIU Bai-chao,SUN Jun-yong. Research for Synthesis of Novel Photosensitizer[J]. Journal of Xinyang Teachers College(Natural Science Edition), 2007, 20(4): 475-478 |
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| Authors: | WANG Hong-jun LIU Bai-chao SUN Jun-yong |
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| Abstract: | A series of novel 2-nitro-5,10,15,20-tetra(3-hydroxyphenyl) metal porphyrins and their complexes as new photosensitizers for photodynamic therapy were synthesized by regioselectivity nitration of 4-benz-porphyrin with nitrate.Yield reached more than 90%.These synthesized compounds were characterized with IR,UV-vis HNMR and MS,and their structures were confirmed. |
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| Keywords: | photosensitizer 2-nitro-5 10 15 20-tetra(3-hydroxyphenyl) metal porphyrin synthesis photodynamic therapy |
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