| 二苯基锗杂环羧酸酯的合成与性质研究 |
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| 引用本文： | 张如芬,张文圣,尹汉东,马春林.二苯基锗杂环羧酸酯的合成与性质研究[J].聊城大学学报(自然科学版),2000(2). |
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| 作者姓名： | 张如芬 张文圣 尹汉东 马春林 |
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| 作者单位： | 聊城师范学院化学系!聊城252059(张如芬，尹汉东，马春林)，德州高等专科学校化学系!德州253023(张文圣) |
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| 基金项目： | 山东省自然科学基金!(Q98B0 1 1 1 7)，晶体材料国家重点实验室资助课题 |
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| 摘 要： | 合成了 8种二苯基锗杂环羧酸酯 Ph2 Ge(O2 CR) 2 (R=2 -呋喃基、2 -呋喃乙烯基、2 -噻吩基、2 -吡啶基、3-吡啶基、4-吡啶基、3-吲哚甲基、3-吲哚丙基 ) ,利用元素分析、红外光谱、核磁共振氢谱和质谱表征了这些化合物的结构 .体外实验表明 ,这些化合物对 MCF- 7和 Wi Dr癌细胞具有较好的抑制活性 .
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| 关 键 词： | 二苯基锗 杂环羧酸酯 合成 生物活性 |
Synthesis and Characterication of Diphenylgermanium Heterocyclic Carboxylates |
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| Zhang Rufen,\ Zhang Wensheng,\ Yin Handong,\ Ma Chunlin.Synthesis and Characterication of Diphenylgermanium Heterocyclic Carboxylates[J].Journal of Liaocheng University:Natural Science Edition,2000(2). |
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| Authors: | Zhang Rufen \ Zhang Wensheng \ Yin Handong \ Ma Chunlin |
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| Institution: | Zhang Rufen 1) \ Zhang Wensheng 2) \ Yin Handong 1) \ Ma Chunlin 1) |
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| Abstract: | Eight new diphenylgermanium heterocyclic carboxylates Ph 2Ge(O 2CR) 2 were synthesized by the reaction of diphenylgermanium dichloride with sodium heterocyclic carboxylate.Their structures were characterized by elementary analysis,IR, 1H NMR and MS spectra.The preliminary antitumor tests in vitro against MCF\|7 and WiDr showed that they were of higher antitumor activities. |
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| Keywords: | Diphenylgermanium Heterocycliccarboxylate Synthesis Bioactivity |
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