Chronic granulomatous disease |
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| Authors: | B H Segal L Romani P Puccetti |
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| Institution: | (1) Departments of Medicine and Immunology, Division of Infectious Diseases, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA;(2) Department of Experimental Medicine, University of Perugia, Perugia, Italy |
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| Abstract: | Chronic granulomatous disease is an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal infections
and disordered inflammation. We propose that NADPH oxidase has a key role in regulating acute neutrophilic and T cell responses,
which in turn restrains fungal growth and calibrates the inflammatory response to minimize injury and allergy. In this model,
superoxide-induced activation of indoleamine 2,3-dioxygenase (IDO) is a central mechanism by which the optimal balance of
antifungal host defense and immune tolerance occurs. This model is based on studies in mice and requires correlation in humans.
Received 18 August 2008; received after revision 29 November 2008; accepted 16 December 2008 |
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| Keywords: | " target="_blank"> Chronic granulomatous disease NADPH oxidase inflammation Interleukin-17 indoleamine 2 3-dioxygenase |
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