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| 猪小肠抗菌肽对SPF鸡肠道黏膜免疫功能的影响 | |
| 引用本文： | 姚俊,王德成,佘锐萍,马卫明.猪小肠抗菌肽对SPF鸡肠道黏膜免疫功能的影响[J].科学技术与工程,2009,9(17). |
| 作者姓名： | 姚俊 王德成 佘锐萍 马卫明 |
| 作者单位： | 1. 云南省畜牧兽医科学院,昆明,650224 2. 中国农业大学动物医学院,北京,100193 3. 山东农业大学动物科技学院,泰安,271018 |
| 基金项目： | 国家自然科学基金，云南省农业科技创新工程 |
| 摘 要： | 60只1日龄的SPF 鸡随机分为两组,来评价添加外源性抗菌肽对其肠道黏膜免疫功能的影响.结果表明:1)十二指肠、空肠和回肠内的上皮内淋巴细胞数量从第21日龄起,与对照组相比差异明显(p<0.05).2)自21日龄起,在抗菌肽处理组可以见到明显的肥大细胞,而在对照组少见(p<0.05).3)抗菌肽的处理能显著增加各段肠道内杯状细胞的数量(p<0.05).4)使用抗菌肽处理后,能提高各段肠道的sIgA的表达.添加外源性的抗菌物质,能显著提高SPF鸡的肠道黏膜免疫参数,并且有助于进一步深入了解抗菌肽对肠道黏膜免疫的调控机制. |
| 关 键 词： | 抗菌肽 上皮内淋巴细胞 肥大细胞 杯状细胞 分泌型IgA |
Effect of Swine Gut Antimicrobial Peptides (SGAMP) on Intestinal Mucosal Immunity of Specific-pathogen-free (SPF) Chickens |
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| YAO Jun,WANG De-cheng,SHE Rui-ping,Ma Wei-ming.Effect of Swine Gut Antimicrobial Peptides (SGAMP) on Intestinal Mucosal Immunity of Specific-pathogen-free (SPF) Chickens[J].Science Technology and Engineering,2009,9(17). | |
| Authors: | YAO Jun WANG De-cheng SHE Rui-ping Ma Wei-ming |
| Institution: | Yunnan Academy of Animal Science and Veterinary Medicine;Kunming 650224;P.R.China;The college of Veterinary Medicine 1;China Agricultural University;Beijing 100193;The college of Animal Science and Technology 2;Shangdong Agricultural University;Taian 271018;P.R.China |
| Abstract: | Sixty specific-pathogen-free(SPF)chickens were randomly divided into two groups(30 chickens for each group)to determine the effect of swine gut antimicrobial peptides(SGAMP)on intestinal mucosal immunity.All chickens were raised in negative-pressure isolators and fed the same diet.The results were as follows:(1)In the SGAMP group,the number of mast cell were increased markedly in the duodenum from day 21 to 49(p <0.05),and similar results were observed in the jejunum and ileum after treated with SGAMP(p <0.... |
| Keywords: | antimicrobial peptides mast cell intraepithelial lymphocytes goblet cell secretory immunoglobulin A |
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