| 慢性应激对小鼠空间学习记忆功能及海马和前额叶皮层BDNF表达的影响 |
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| 引用本文： | 徐芸,孔宏,宋倩,李亚.慢性应激对小鼠空间学习记忆功能及海马和前额叶皮层BDNF表达的影响[J].曲阜师范大学学报,2009,35(1):85-89. |
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| 作者姓名： | 徐芸 孔宏 宋倩 李亚 |
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| 作者单位： | 曲阜师范大学生命科学学院,273165,山东省曲阜市
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| 基金项目： | 曲阜师范大学科研基金 |
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| 摘 要： | 采用多因素慢性应激动物模型，通过Morris水迷宫测试小鼠空间学习记忆能力；采用免疫组织化学方法检测脑源性神经营养因子（BDNF）在海马和前额叶皮层的表达．结果显示，与对照组相比，应激组小鼠的空间学习记忆能力明显下降（P〈0．01）；应激组小鼠海马CA1区、齿状回和前额叶皮层BDNF表达明显下降（P〈0．01）；停止应激后一周，应激组小鼠BDNF在各脑区的表达有一定恢复，但与对照组相比，仍有显著性差异（P〈0．05，P〈0．01）．结果表明，慢性应激导致小鼠空间学习记忆功能的损伤可能与BDNF表达的下调密切相关．
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| 关 键 词： | 慢性应激 空间学习记忆 脑源性神经营养因子 海马 前额叶皮层 |
Effects of Chronic Stress on Ability of Spatial Learning-Memory and Expression of Brain Derived Neurotrophic Factor in The Hippocampus and Prefrontal Cortex of Mice |
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| XU Yun,KONG Hong,SONG Qian,LI Ya.Effects of Chronic Stress on Ability of Spatial Learning-Memory and Expression of Brain Derived Neurotrophic Factor in The Hippocampus and Prefrontal Cortex of Mice[J].Journal of Qufu Normal University(Natural Science),2009,35(1):85-89. |
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| Authors: | XU Yun KONG Hong SONG Qian LI Ya |
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| Institution: | College of Life Sciences;Qufu Normal University;273165;Qufu;Shandong;PRC |
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| Abstract: | This paper mainly stnded study the effects of chronic stress on the ability of spatial learning and memory of mice using Morris water maze,and the expression of brain derived neurotrophic factor(BDNF) in the hippocampus and prefrontal cortex(PFC) by immunohistochemical method.The results showed that compared with control group,the ability of spatial learning and memory were significantly decreased(P<0.01);and the BDNF expression in the CA1 region and dentate gyrus of hippocampus and PFC were significantly r... |
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| Keywords: | chronic stress spatial learning and memory BDNF hippocampus PFC |
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