TSH-Receptor antibodies,HLA B8 and thyroid autoantibodies in patients with Graves' disease in therapeutically induced euthyroidism |
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| Authors: | G Schernthaner H Ludwig H Schleusener R Finke P Kotulla W R Mayr |
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| Institution: | (1) Department of Medicine II, University of Vienna, Garnisongasse 13, A-1090 Vienna, Austria;(2) Department of Endocrinology, Klinikum Steglitz, Free University of Berlin, Berlin, West Germany;(3) Institute of Blood Group Serology, University of Vienna, Austria |
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| Abstract: | Summary The prevalence of TSH-receptor antibodies and of thyroid autoantibodies was studied in 48 HLA-typed patients with Graves' disease, who were in an euthyroid state after antithyroid therapy with methimazole. TSH-receptor antibodies, which were found in 35% of the patients, did not correlate with the positivity of HLA B8. By contrast the persistence of thyroid microsomal antibodies was significantly associated with HLA B8. |
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