| TiO2光化自由基对U937细胞氧化压迫凋亡研究 |
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| 引用本文： | 徐敏华,黄宁平.TiO2光化自由基对U937细胞氧化压迫凋亡研究[J].东南大学学报(自然科学版),1997,27(4):15-18. |
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| 作者姓名： | 徐敏华 黄宁平 |
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| 作者单位： | 东南大学分子与生物分子电子学开放研究实验室 |
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| 摘 要： | ＴｉＯ２纳米超微粒在３００￣４００ｎｍ紫外光照激发下所产生的光生电子空穴对具有极强的光催化反应性能，受其光催化作用，大量活性氧类自由基在细胞内累积，形成细胞内氧化压迫并最终导致细胞凋亡，本研究观察分析了ＴｉＯ２超微粒光激发自由基与氧化压迫性细胞凋亡的关系，并对其作用机制作了初步的探讨。
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| 关 键 词： | 二氧化钛 光化作用 自由基 U937细胞 细胞凋亡 |
Radicals Produced by Photoexcited TiO 2 Particles to Oxidatively Stress U937 Cell to Apoptosis |
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| Xu Minhua,Huang Ningping,Gu Jianhua.Radicals Produced by Photoexcited TiO 2 Particles to Oxidatively Stress U937 Cell to Apoptosis[J].Journal of Southeast University(Natural Science Edition),1997,27(4):15-18. |
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| Authors: | Xu Minhua Huang Ningping Gu Jianhua |
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| Abstract: | The electron hole pairs generated upon photoexcited nanometer material TiO 2 can effectively induce the monocytic leukemia cells to apoptosis. The average diameter of ultrafine TiO 2 particles prepared by nanometer technology in this study was about 15 nm, and the U937 cell line was used as a subject. TiO 2 particles were proved to be able to oxidatively stress the malignant cells to apoptosis. The mechanism for oxidative stress induced apoptosis by TiO 2 was discussed. The results revealed that photoexcited TiO 2 can catalyze water attached on TiO 2 to produce reactive oxygen species, which are the main reason for stressing cell programmed death. |
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| Keywords: | TiO 2 free radicals / photoexcitel U937 cells apoptosis |
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