Heat shock protein gene expression during embryonic development of the zebrafish |
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Authors: | PH Krone JB Sass Z Lele |
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Institution: | (1) Department of Anatomy and Cell Biology, University of Saskatchewan, Health Sciences Building, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5 (Canada), Fax +1 306 966 4298, e-mail: krone@duke.usask.ca, CA |
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Abstract: | Heat shock genes exhibit complex patterns of spatial and temporal regulation during embryonic development of a wide range
of organisms. Our laboratory has been involved in an analysis of heat shock gene expression in the zebrafish, a model system
which is now utilized extensively for the examination of early embryonic development of vertebrates. Members of the zebrafish
hsp47, hsp70 and hsp90 gene families have been cloned and shown to be closely related to their counterparts in higher vertebrates.
Expression of these genes has been examined using Northern blot and whole mount in situ hybridization analyses. Both the hsp47
and hsp90 genes are expressed in a highly tissue-restricted manner during normal development. The data raise a number of interesting
questions regarding the function and regulation of these heat shock genes during early zebrafish development. |
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Keywords: | , Zebrafish, heat shock, myogenesis, developmental biology, hsp90, hsp70, hsp47, |
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