Aldose metabolism in developing human fetal brain and liver |
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| Authors: | B. K. Samanta N. C. Chandra S. Ghosh K. L. Mukherjee |
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| Affiliation: | (1) Department of Biochemistry, Institute of Post Graduate Medical Education and Research, 700 020 Calcutta, (India);(2) Present address: Department of Biochemistry, Institute of Child Health, 700 017 Calcutta, (India) |
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| Abstract: | Summary Aldose reductase, sorbitol dehydrogenase, and glucose-6-phosphate dehydrogenase enzyme activities were studied in human foetal brain and liver at different periods of gestation. Aldose reductase activity in liver disappears after 16 weeks of gestation whereas sorbitol dehydrogenase keeps on increasing in liver as well as in brain. In utero, some glucose metabolism may be mediated through an active sorbitol pathway in human fetuses.Acknowledgments. These studies were supported by the Indian Council of Medical Research. |
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| Keywords: | Fetal development brain, human liver, human aldose metabolism sorbitol pathway |
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