Evidence against cyclic GMP acting as a direct modulator of active sodium absorption in rat cecum |
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| Authors: | P Blümel R Gerzer K Loeschke |
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| Institution: | (1) Medizinische Klinik Innenstadt der Universität München, Ziemssenstr. 1, D-8000 München 2, (Federal Republic of Germany);(2) Present address: Pharmakologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 366, D-6900 Heidelberg, FRG |
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| Abstract: | Summary Cyclic GMP concentrations were measured in rat cecum mucosa in vivo when the net absorption of sodium, chloride and fluid was stimulated by methylprednisolone (MP). Whereas Na–K-ATPase specific activity was increased by MP, suggesting enhanced active sodium transport, cyclic GMP levels remained unaffected.Acknowledgments. We thank Miss U. Kautz for engaged technical assistance and Dr G. Schultz for valuable discussions.Supported by Deutsche Forschungsgemeinschaft grant Lo 114/10. |
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