Effect of insulin on immunological phagocytosis by macrophages |
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| Authors: | A Oliveira Lima M Queiroz H M Bräscher J Vargens |
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| Institution: | (1) Centro de pesquisas Arlindo de Assis (FAP), Av. Almirante Barroso 54, Rio de Janeiro, (Brazil);(2) Instituto de Puericultura e Pediatria, U.F.R.J., Rio de Janeiro, (Brazil) |
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| Abstract: | Summary It was shown that, in physiological concentrations, insulin enhances, in vitro, the immunological phagocytosis of sensitized sheep erythrocytes by cultured mouse peritoneal macrophages. Insulin seems to stimulate macrophage phagocytosis as a cholinomimetic agonist by increasing the intracellular levels of cyclic GMP.Acknowledgments. This investigation was supported by a grant from the National Council for Cientific and Tecnological Development (CNPq), Rio de Janeiro, Brazil. |
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