饮用咖啡与胰腺癌患病的Meta分析

目的 综合评价饮用咖啡因素与胰腺癌发生的相关性,进一步探讨胰腺癌的危险因素.方法 检索1970.01.01/2010.10.01国内外公开发表的有关人群饮用咖啡和胰腺癌发生的病例对照研究,制定纳入标准,采用Rev Man4.2软件对研究资料进行Meta分析,定量综合评价饮用咖啡与胰腺癌的关系.结果 共有15组病例-对照研究符合入选标准,累积胰腺癌病例共3 335例和正常对照者共15 064例.Meta分析显示,合并OR=1.08(95％ CI:0.88～1.31),(P=0.48),差异无统计学意义；男性组结果显示,OR和95％ CI为1.14(0.95-1.37),差距不具有统计学意义(P=0.15),女性组结果显示OR和95％CI为1.18(0.98-1.43),(P=0.09),由于P＜0.1,故属于边缘性显著差异.结论 女性胰腺癌患者中有饮用咖啡习惯与无饮用咖啡习惯的人相比,饮用咖啡的习惯可能会增加胰腺癌的发病风险.

The Meta-analysis of the Coffee Drinking Habit and Pancreatic Carcinoma

Objective To evaluate the relationship between the habit of coffee drinking and pancreatic carcinoma and to explore the risk factors of pancreatic cancer. Methods We searched for the related articles of case-control study on the coffee drinking and pancreatic carcinoma be- tween 1970.01.01and 2010.10.01 published at home and abroad. Criterias was made and Meta analysis was performed to evaluate the asso- ciation between the coffee drinking and pancreatic carcinoma by using the software of RevMan4.2. Results Altogether 15 articles of ease-con- trol study were included according to the criteria we made. This artile included 3 335 patients of pancreatic carcinoma and 15 064 normal. The Meta-analysis showed that ： the pooled odds ratio （OR） and confidence interval （ 95 % CI ） werel. 08 （ 95 % CI ： 0. 88 - 1.31 ）, （ P = 0. 48 ）. In the man group, the pooled odds ratio （OR） and confidence interval（95 % CI） were 1.14 （0. 95 - 1.37 ）, （ P = 0. 15 ）. In the woman group, the pooled odds ratio （ OR ） and confidence interval （ 95 % CI） were 1.18 （ 0. 98 - 1.43 ）, （ P = 0. 09 ）, P 〈 0. 1. Conclusion Compared with the pancreatic carcinoma patients of non coffee drinking habit, our study indicate that in the woman group the habit of coffee drinking maybe a risk factor for the development of the pancreatic carcinoma.