Investigation of biomembrane-drug interactions of different biomembranes by capillary electrophoresis

Biomembrane-coated capillaries are prepared by coating different kinds of biomembranes including mice red cell membrane, human red cell membrane and S-180 cell membrane on the inner surface of the capillary, respectively. Effects of immobilized biomembrane amount, pH and biomembrane species on the interactions between drugs and biomembranes have been evaluated. The results showed that the chromatographic retention factor for each drug was essentially related to the amount of immobilized biomembrane, the pH and the type of biomembrane. Supported by the National Natural Science Foundation of China (Grant Nos. 20375010, and 20675084), Program for Science and Technology Development of Hebei Province (Grant Nos. 06276479B and 07276407D) and “Bai Ren Project” of Chinese Academy of Sciences