Role of heregulin in human cancer |
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Authors: | M Breuleux |
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Institution: | (1) Novartis Institutes for Biomedical Research (NIBR), Oncology, WKL-125.12.59, Klybeckstrasse 141, 4002 Basel, Switzerland |
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Abstract: | Heregulin (HRG) is a soluble secreted growth factor, which, upon binding and activation of ErbB3 and ErbB4 transmembrane receptor
tyrosine kinases, is involved in cell proliferation, invasion, survival and differentiation of normal and malignant tissues.
The HRG gene family consists of four members: HRG-1, HRG-2, HRG-3 and HRG-4, of which a multitude of different isoforms are synthesized by alternative exon splicing, showing various tissue distribution
and biological activities. Disruption of the physiological balance between HRG ligands and their ErbB receptors is implicated
in the formation of a variety of human cancers. The general mechanisms involved in HRG-induced tumorigenesis is discussed.
Received 8 March 2007; received after revision 6 May 2007; accepted 9 May 2007 |
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Keywords: | Heregulin growth factor signaling strategies ErbB tumorigenesis |
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