Constrained oscillation of a bubble subjected to shock wave in microvessel

A three-phase coupled model of the gas–liquid–solid oscillation system is established to analyze the oscillation characteristics of a bubble inside a micro blood vessel with various radii and its shape changes with different interface boundaries. The results show that unlike the spherical symmetric oscillation in an unbounded fluid, the oscillating bubble has significant asymmetric characteristics under the constraint of a flexible microvessel, especially while its radius reduces to the same order of magnitude as that of the bubble. Moreover, the variation of microbubble motion, whether the geometric shape or oscillation feature, exhibits obvious differences in the micro blood vessel compared with the rigid wall. The reasons behind these phenomena are analyzed in this paper. The conclusions have significant importance in the understanding of the mechanism of microvessel injury in ultrasound therapy.