Telomeres and meiosis in health and disease |
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Authors: | D L Keefe |
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Institution: | (1) Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Harbourside Medical Tower, 514, 4 Columbia Drive, Tampa, Florida 33606, USA |
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Abstract: | Telomeres are important segments of chromosomes that protect chromosome ends from nucleolytic degradation and fusion. At meiosis
telomeres display an unprecedented behavior which involves their attachment and motility along the nuclear envelope. The movements
become restricted to a limited nuclear sector during the so-called bouquet stage, which is widely conserved among species.
Recent observations suggest that telomere clustering involves actin and/or microtubules, and is altered in the presence of
impaired recombinogenic and chromosome related functions. This review aims to provide an overview of what is currently known
about meiotic telomere attachment, dynamics and regulation in synaptic meiosis. |
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Keywords: | Actin bouquet chromosome dynamics nuclear envelope attachment meiosis pairing telomere |
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