Profound hypothermia in golden hamsters (Mesocricetus auratus) induced by serotonergic potentiating and noradrenergic inhibiting drugs |
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| Authors: | J T Burns A H Meier |
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| Institution: | (1) Department of Anatomy, West Virginia School of Osteopathic Medicine, 400 North Lee Street, 24901 Lewisburg, West Virginia, USA;(2) Department of Zoology and Physiology, Louisiana State University, 70803 Baton Rouge, Louisiana, USA |
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| Abstract: | Summary Profound hypothermia (6°C) was induced in cold exposed golden hamsters (Mesocricetus auratus) by a combination of drugs that potentiate brain serotonergic activity (fluoxetine and pargyline) and inhibit noradrenergic activity (alpha-methyl-p-tyrosine). Individual drugs and combinations of 2 were ineffective.Acknowledgements. We acknowledge the support of a research grant PCM74-05158 A01 to A.H.M. from the National Science Foundation (USA) and thank Lilly Research Laboratories, Indianapolis, Indiana, for the gift of fluoxetine (Lilly 110140). |
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