| 高分子药物的研究：5－丙烯酰胺基水杨酸聚合物的合成 |
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| 引用本文： | 王京芳,胡志国.高分子药物的研究：5－丙烯酰胺基水杨酸聚合物的合成[J].河南师范大学学报(自然科学版),1996,24(4):95-97. |
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| 作者姓名： | 王京芳 胡志国 |
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| 摘 要： | 合成了单体５－丙烯酰胺基水杨酸及其聚合物，用红外光谱、核磁共振谱、质谱和元素分析等确定了这些物质的结构．聚合物水解实验表明，它们在酸性、中性和碱性介质中均能水解，水解速率（γ）的大小依次为：γｐＨ＝１３．０＞γｐＨ＝７．０＞γｐＨ＝２．０。
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| 关 键 词： | 高分子药物 5－丙烯酰胺基水杨酸 聚合物 缓慢释放 水解 |
Chemotherapeutic Polymer The Study of Poly(5-acryloylamino Salicylic Acid) |
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| Abstract: | In this work, 5-acryloylamino salicylic acid monomer, its copolymer with acrylamine were synthesized. The structure characteristics of them were investigated by IR, 1H-NMR, MS, Hydrolys is of polymers in acidic, alkaline and neutral media was measured by UV. The results show that the hydrolysis rate (γ) was γpH=13. 0>γpH=7.0>γpH=2.0. |
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| Keywords: | polymer drugs 5-Acryloylamino salicylic acid hydrolysis sustained release polymer |
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