| 5-氟尿嘧啶衍生物的合成及其抗癌活性研究进展 |
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| 引用本文： | 扈靖,刘彦钦,韩士田,扈琳.5-氟尿嘧啶衍生物的合成及其抗癌活性研究进展[J].河北师范大学学报(自然科学版),2006,30(5):580-584. |
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| 作者姓名： | 扈靖 刘彦钦 韩士田 扈琳 |
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| 作者单位： | 河北师范大学,化学与材料科学学院,河北,石家庄,050016;医院,河北,石家庄,050000 |
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| 摘 要： | 5-氟尿嘧啶(5-FU)是临床上一种抗瘤谱广、有效率高的抗代谢药物.它对多种肿瘤有抑制作用,缺陷是服药有效剂量与中毒量相近,在杀死癌细胞的同时对正常细胞的损伤也较严重.提高5-FU的选择性、最大限度地避免药物的副作用已成为人们的研究重点.对近年来已研究的5-氟尿嘧啶衍生物的合成及其抗癌活性进行了综述和评论.
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| 关 键 词： | 5-FU 衍生物 抗癌活性 |
| 文章编号： | 1000-5854(2006)05-0580-05 |
| 收稿时间： | 2005-08-26 |
| 修稿时间： | 2005-10-17 |
Synthesis and Antitumor Activity Development of 5- fluorouracil Derivatives |
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| HU Jing,LIU Yan-qin,HAN Shi-tian,HU Lin.Synthesis and Antitumor Activity Development of 5- fluorouracil Derivatives[J].Journal of Hebei Normal University,2006,30(5):580-584. |
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| Authors: | HU Jing LIU Yan-qin HAN Shi-tian HU Lin |
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| Institution: | 1. College of Chemistry and Material Sciences, Hebei Normal University, Hebei Shijiazhuang 050016,China; 2.The Second Hospital,Hebei Medical University,Hebei Shijiazhuang 050000,China |
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| Abstract: | 5-fluorouracil(5-FU) is a kind of antimetabolic drug used in clinic.5-FU has inhibition effect on many kinds of cancer,but it also seriously hurts the normal cells while it kills the cancer cells.More attention has been paid to improve the target activity of 5-FU and reduce its side effects.The synthesis and antitumor activity development of 5FU derivatives in recent years is reviewed and discussed. |
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| Keywords: | 5 - FU derivatives antitumor activity |
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