Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis |
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Authors: | Sabine D Jordan A Christine Könner Jens C Brüning |
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Institution: | 1. Department of Mouse Genetics and Metabolism, Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Zülpicher Stra?e 47, 50674, Cologne, Germany 2. Center of Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany 3. 2nd Department for Internal Medicine, University Hospital Cologne, Cologne, Germany 4. Max Planck Institute for the Biology of Aging, Cologne, Germany
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Abstract: | The central nervous system (CNS) is capable of gathering information on the body’s nutritional state and it implements appropriate
behavioral and metabolic responses to changes in fuel availability. This feedback signaling of peripheral tissues ensures
the maintenance of energy homeostasis. The hypothalamus is a primary site of convergence and integration for these nutrient-related
feedback signals, which include central and peripheral neuronal inputs as well as hormonal signals. Increasing evidence indicates
that glucose and lipids are detected by specialized fuel-sensing neurons that are integrated in these hypothalamic neuronal
circuits. The purpose of this review is to outline the current understanding of fuel-sensing mechanisms in the hypothalamus,
to integrate the recent findings in this field, and to address the potential role of dysregulation in these pathways in the
development of obesity and type 2 diabetes mellitus. |
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Keywords: | |
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