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| 环磷酰胺致BALB/c小鼠肝损伤的组织学研究 | |
| 引用本文： | 叶明霞,陶迎红,周顺长,孔利佳,许迪,阮秋蓉.环磷酰胺致BALB/c小鼠肝损伤的组织学研究[J].实验动物科学,2008,25(2):7-9. |
| 作者姓名： | 叶明霞 陶迎红 周顺长 孔利佳 许迪 阮秋蓉 |
| 作者单位： | 1. 华中科技大学同济医学院实验动物学部,武汉,430030 2. 北京大学第一医院动物室,北京,100034 3. 华中科技大学同济医学院基础医学院病理教研室,武汉,430030 |
| 摘 要： | 目的研究环磷酰胺(CTX)对BALB/c小鼠肝组织的病理作用。方法BALB/c小鼠腹腔注射CTX 15 mg.kg-1.d-1连续8 d,停药8 d后取肝组织,HE染色镜检,观察病理学改变。结果CTX致肝组织广泛性的中度~重度水变性;肝窦受挤压,结构不清;灶状坏死,炎性细胞浸润。结论CTX对BALB/c小鼠肝脏存在组织结构损害。 |
| 关 键 词： | 环磷酰胺 BALB/c小鼠 |
| 文章编号： | 1006-6179(2008)02-0007-03 |
| 收稿时间： | 2008-04-28 |
| 修稿时间： | 2007年6月11日 |
Histopathological Observation on Hepatic lesions Induce by Cyclophosphamide in BALB/c Mice |
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| YE Ming-xia,TAO Ying-hong,ZHOU Shun-chang,KONG Li-jia,XU Di,RUAN Qiu-rong.Histopathological Observation on Hepatic lesions Induce by Cyclophosphamide in BALB/c Mice[J].Shiyan Dongwu Kexue,2008,25(2):7-9. | |
| Authors: | YE Ming-xia TAO Ying-hong ZHOU Shun-chang KONG Li-jia XU Di RUAN Qiu-rong |
| Institution: | YE Ming-xia~1,TAO Ying-hong~2,ZHOU Shun-chang~1,KONG Li-jia~1,XU Di~1,RUAN Qiu-rong~3(1.Faculty of Laboratory Animal,Tongji Medical College of Huazhong University of Science , Technology,Wuhan 430030,China)(2.Department of Laboratory Animal,the First Hospital,Beijing University)(3.Pathological Department of Preclinical Medicine School of Tongji Medical College ofHuazhong University of Science , Technology,China) |
| Abstract: | Objective To investigate pathological lesions of liver induced by cyclophosphamide in BALB/c mice.Methods Cyclophosphamide was intraperitoneally administered to BALB/c mice in a dose 15 mg/kg once daily for 8 days.Eight days later, the mice were sacrificed and their livers were subjected to paraffin sections stained with hematoxylin and eosine to examine hepatic lesions under light microscopy.Results Some pathological lesions such as focal necrosis and interstitial inflammatory cell infiltration and so on ... |
| Keywords: | Cyclophosphamide BALB/c mice Liver Pathological change |
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