Possible role of intestinal alkaline phosphatase activity in thiamine transport |
| |
Authors: | T. Matsuda A. Baba H. Iwata |
| |
Affiliation: | (1) Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 133-1, Yamada-kami, Suita-shi, Osaka, (Japan) |
| |
Abstract: | Summary Thiamine deficiency caused a marked decrease of intestinal alkaline phosphatase (al-Pase) activity, but had no effect on the Ca++-ATPase activity and Ca++-absorption in rats. The al-Pase activity was significantly decreased 1 h after oral administration of ethanol at 0.5 and 2.5 g/kg. In contrast, Mg++-, Ca++- and (Na++K+)-ATPase activities did not change after the administration of ethanol. These findings show that the al-Pase activity, unlike the Ca++-ATPase activity, is not related to Ca++-absorption. A possible role of al-Pase activity in the active transport of thiamine in the intestine was discussed. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|