Vaults and the major vault protein: Novel roles in signal pathway regulation and immunity |
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Authors: | W Berger E Steiner M Grusch L Elbling M Micksche |
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Institution: | (1) Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria |
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Abstract: | The unique and evolutionary highly conserved major vault protein (MVP) is the main component of ubiquitous, large cellular
ribonucleoparticles termed vaults. The 100 kDa MVP represents more than 70% of the vault mass which contains two additional
proteins, the vault poly (ADP-ribose) polymerase (vPARP) and the telomerase-associated protein 1 (TEP1), as well as several
short untranslated RNAs (vRNA). Vaults are almost ubiquitously expressed and, besides chemotherapy resistance, have been implicated
in the regulation of several cellular processes including transport mechanisms, signal transmissions and immune responses.
Despite a growing amount of data from diverse species and systems, the definition of precise vault functions is still highly
complex and challenging. Here we review the current knowledge on MVP and vaults with focus on regulatory functions in intracellular
signal transduction and immune defence.
Received 27 June 2008; received after revision 25 July 2008; accepted 30 July 2008 |
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Keywords: | " target="_blank"> Vault particles major vault protein signal pathway regulation immunity drug resistance |
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